We are engaged in the endeavor of trying to elucidate secondary structure changes in proteins by combining various spectroscopic and multivariate analytical methodologies found in our toolbox. A major emphasis in this regard is the use and advancement of UV excited Raman (UVRR) spectroscopy and multiway chemometrics to study protein dynamics and peptide-small molecule interactions. We believe these complimentary techniques are extremely well suited for structural analysis where problem peptides like those exhibiting steady state disorder (which don't form crystals that diffrect X-rays or stay still enough for n-dimensional NMR structure determination) as well as in those cases where transient interactions/binding events dicretely alter the global secondary structure equilibrium.